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Phase III Study Primary Endpoints

Success in ISGA: Clear or almost clearStudy Design

Phase III Study Secondary Endpoints

ISGA clear or almost clearTime to ISGA success
Phase III Study: Other EndpointsPruritusQuality of life assessmentsInfant Study: Exploratory EndpointsISGA clear or almost clear%BSA, EASI & POEM
Safety DataSafety DataPhase III Study Adverse Reactions*Pivotal trial & 48-week extension study Adverse ReactionsOpen-Label Safety Extension Study*Open-Label Safety Extension Study Rescue Therapy EndpointStudy designInfant Safety Study**Adverse ReactionsStudy design and DemographicsReal-World PatientsReal-world patient case reportsReal-world patient case studiesNana's experience with EucrisaBraxton's testimonialHand and fingerFace and neckOtherHand and finger5-yr-old Caucasian female - hands8-yr-old Caucasian female - hands15-yr-old Caucasian male - hand55-yr-old Caucasian female - hand64-yr-old Caucasian female - thumb70-yr-old Caucasian male - thumbFace and neck15-yr-old Caucasian male - chin18-yr-old Hispanic female - face and neck75-yr-old Caucasian male - faceOther39-yr-old Asian male - arm44-yr-old African American female - legs72-yr-old Caucasian female - legDosingSavings & SupportSavings & SupportEventsMaterialsVideosCopay CardsCost and Coverage
Prescribing InformationPatient Information Indication Patient Site
EUCRISA EfficacySteroid-Free EUCRISA has proven efficacy in patients ≥ 2 yearsOverviewAbout ISGABaseline CharacteristicsEUCRISA was studied across a spectrum of patientsEUCRISA baseline characteristics in pivotal trials2
TRIAL 1 AND TRIAL 2 POOLEDa Crisaborole, 2%
Vehicle (n=506)
Crisaborole, 2%
Vehicle (n=506)
Age (years)
Mean (SD) 12.3 (12.16) 12.1 (11.65)
Median 9.0 9.0
Min to max 2 to 79 2 to 79
2-11 years 627 (61.7%) 315 (62.3%)
  • 2-6 years
335 (33.0%) 171 (33.8%)
  • 7-11 years
292 (28.7%) 144 (28.5%)
12-17 years 335 (33.0%) 171 (33.8%)
>18 years 142 (14.0%) 67 (13.2%)

Male 450 (44.3%) 225 (44.5%)
Female 566 (55.7%) 281 (55.5%)


Not Hispanic or Latino 816 (80.3%) 405 (80.0%)
Hispanic or Latino 200 (19.7%) 101 (20%)


White 617 (60.7%) 306 (60.5%)
Black or African American 285 (28.1%) 139 (27.5%)
Asian 52 (5.1%) 27 (5.3%)
Otherb 44 (4.3%) 21 (4.2%)
Native Hawaiian or Pacific Islander 7 (0.7%) 8 (1.6%)
American Indian or Alaska Native 11 (1.1%) 5 (1.0%)

Trial 1 and Trial 2 pooled data.Includes American Indian, Alaska Native, Native Hawaiian, Pacific Islander, or Other.SD=standard deviation.ReferencesEUCRISA® (crisaborole) Full Prescribing Information. December 2018.Data on file. Pfizer Inc., New York, NY.Schlessinger J, Shepard JS, Gower R, et al. Safety, effectiveness, and pharmacokinetics of crisaborole in infants aged 3 to <24 months with mild-to-moderate atopic dermatitis: a phase IV open-label study (CrisADe CARE 1). Am J Clin Dermatol. 2020. 21:275-284.Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):338-351.Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(1):116-132.
Efficacy Pivotal Trial Primary Efficacy Endpoint

Find out more about the proportion of patients who achieved clear or almost clear at day 29 in the primary endpoint

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If babies could talk, what would they tell you?

Hear JP with mild-to-moderate AD explain what EUCRISA means to him and other babies like him

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Not an actual patient

3 to <24 Month Study Data

Learn more about 28-day, open-label, single-arm, safety study in 3 to <24 month old patients14

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Learn how the first and only nonsteroidal topical PDE4 inhibitor works within the skin1

The specific mechanism(s) of action of crisaborole in atopic dermatitis is not well defined. PDE4=phosphodiesterase 4

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Copay Cards

*Eligible patients pay as little as $10​​​​​​

Download Copay cards LoadingPatients enrolled in state or federally funded prescription insurance programs are not eligible to use this card. Savings up to $970 per tube. Annual savings up to $3,880. This card will be accepted only at participating pharmacies. This card is not health insurance.
Savings & Support Program

A savings and support program for your patients to help them with their access to EUCRISA

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EUCRISA (crisaborole) is indicated for topical treatment of mild-to-moderate atopic dermatitis in adult and pediatric patients 3 months of age and older.

EUCRISA is for topical use only and is not for ophthalmic, oral, or intravaginal use. For more information, please view the full prescribing information here.

Important Safety Information


EUCRISA is contraindicated in patients with known hypersensitivity to crisaborole or any component of the formulation.

Warnings and Precautions

Hypersensitivity reactions, including contact urticaria, have occurred in patients treated with EUCRISA and should be suspected in the event of severe pruritus, swelling, and erythema at the application site or at a distant site. Discontinue EUCRISA immediately and initiate appropriate therapy if signs and symptoms of hypersensitivity occur.

Adverse Reactions

The most common treatment-related adverse reaction occurring in clinical trials was application site pain, such as burning or stinging.

Please see Full Prescribing Information and Patient Information

Indication EUCRISA is indicated for topical treatment of mild-to-moderate atopic dermatitis in adult and pediatric patients 3 months of age and older.

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