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HomeEfficacy

Phase III Study Primary Endpoints

Success in ISGA: Clear or almost clearStudy Design

Phase III Study Secondary Endpoints

ISGA clear or almost clearTime to ISGA successPhase III Study: Other EndpointsPruritusQuality of life assessmentsInfant Study: Exploratory EndpointsISGA clear or almost clear%BSA, EASI & POEMSafety DataSafety DataPhase III Study Adverse Reactions*Pivotal trial & 48-week extension study Adverse ReactionsOpen-Label Safety Extension Study*Open-Label Safety Extension Study Rescue Therapy EndpointStudy designInfant Safety Study**Adverse ReactionsStudy design and DemographicsReal PatientsReal patient case reportsReal patient case studiesNana's experience with EucrisaBraxton's testimonialHand and fingerFace and neckOtherHand and finger5-yr-old Caucasian female - hands8-yr-old Caucasian female - hands15-yr-old Caucasian male - hand55-yr-old Caucasian female - hand64-yr-old Caucasian female - thumb70-yr-old Caucasian male - thumbFace and neck15-yr-old Caucasian male - chin18-yr-old Hispanic female - face and neck75-yr-old Caucasian male - faceOther39-yr-old Asian male - arm44-yr-old African American female - legs72-yr-old Caucasian female - legDosingSavings & SupportSavings & SupportEventsMaterialsVideosCopay CardsCost and Coverage
Prescribing InformationPatient Information Indication Patient Site
EUCRISA Safety DataSafety profile established in 4 studies, including pivotal and open-label safety extension studies, and an open-label infant safety studyEUCRISA safety data for the 4-week pivotal trials*,1,2

See Pivotal Trials study design

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PIVOTAL TRIALS ADVERSE REACTIONS IN ≥1% PATIENTS
  EUCRISA (n=1012) Vehicle (n=499)
APPLICATION SITE PAIN1
Refers to skin sensations such
as burning or stinging		 4% (n=45) 1% (n=6)
  • Application site pain resolved within 1 day for 77.6% of patients reporting it3
  • Discontinuation rates due to adverse events were 1.2% for both EUCRISA and vehicle in a pooled analysis3
This pooled data reflects information from Trial 1 and Trial 2 of the pivotal trials where patients enrolled were 2
years and older
EUCRISA safety data for patients enrolled in the Open-Label Safety Extension study1,4

See Open-Label Safety Extension study design

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TREATMENT-RELATED ADVERSE EVENTS OCCURRING IN ≥1% OF PATIENTS IN THE OPEN LABEL SAFETY EXTENSION STUDY
EUCRISA (n=517)  
APPLICATION SITE PAIN2
Refers to skin sensations such as burning or stinging		 2% (n=12)
APPLICATION SITE INFECTION2 1% (n=6)
ATOPIC DERMATITIS2 3% (n=16)
  • In the Open-Label Safety Extension Study:
    • There were no reports of application site cutaneous adverse reactions of atrophy or telangiectasia4†‡
    • Discontinuation rate due to adverse events was 1.7% for EUCRISA3
    • Seven treatment-emergent SAEs occurred in the open-label safety extension study, but none were considered related to treatment4
SAE=serious adverse event
Patients enrolled in the open label safety extension study were enrolled following the pivotal trial and were followed for 48 weeks. The total period followed was 52 weeks.
This pooled data reflects information from Trial 1 and Trial 2 of the pivotal trials where patients enrolled were 2 years and olderAs per verbatim terms coded using the Medical Dictionary for Regulatory Activities (MedDRA) by System Organ Class/Preferred Term.One treatment-emergent adverse event of skin striae at application site was reported (possibly related to study drug).
ReferencesEUCRISA® (crisaborole) Full Prescribing Information. April 2020.Data on File. Pfizer Inc., New York, NY.Paller AS, Tom WL, Lebwohl MG, et al. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. J Am Acad Dermatol. 2016;75(3):494-503.e4.Schlessinger J, Shepard JS, Gower R, et al. Safety, effectiveness, and pharmacokinetics of crisaborole in infants aged 3 to <24 months with mild-to-moderate atopic dermatitis: a phase IV open-label study (CrisADe CARE 1). Am J Clin Dermatol. 2020. 21:275-284.
Safety Data If babies could talk, what would they tell you?

Hear JP with mild-to-moderate AD explain what EUCRISA means to him and other babies like him

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Not an actual patient

 Rescue Therapy Endpoint

Read about rescue therapy in the 48 week Open-Label Safety Extension study

Learn moreLoading Exploratory Pruritus Endpoint

Find out more about the time to relief in pruritus as found in the Phase III study's exploratory endpoint

Learn moreLoading Learn how the first and only nonsteroidal topical PDE4 inhibitor works within the skin1

The specific mechanism(s) of action of crisaborole in atopic dermatitis is not well defined. PDE4=phosphodiesterase 4

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*Eligible patients pay as little as $10​​​​​​

Patients enrolled in state or federally funded prescription insurance programs are not eligible to use this card. Savings up to $970 per tube. Annual savings up to $3,880. This card will be accepted only at participating pharmacies. This card is not health insurance.
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Savings & Support Program

A savings and support program for your patients to help them with their access to EUCRISA

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PP-EUC-USA-0032
INDICATION

EUCRISA (crisaborole) is indicated for topical treatment of mild-to-moderate atopic dermatitis in adult and pediatric patients 3 months of age and older.

EUCRISA is for topical use only and is not for ophthalmic, oral, or intravaginal use. For more information, please view the full prescribing information here.

Indication EUCRISA (crisaborole) is indicated for topical treatment of mild‑to‑moderate atopic dermatitis in adult and pediatric patients 3 months of age and older. EUCRISA is for topical use only and is not for ophthalmic, oral, or intravaginal use. For more information, please view the full prescribing information here.
Important Safety Information

Contraindications

EUCRISA is contraindicated in patients with known hypersensitivity to crisaborole or any component of the formulation.

Warnings and Precautions

Hypersensitivity reactions, including contact urticaria, have occurred in patients treated with EUCRISA and should be suspected in the event of severe pruritus, swelling, and erythema at the application site or at a distant site. Discontinue EUCRISA immediately and initiate appropriate therapy if signs and symptoms of hypersensitivity occur.

Adverse Reactions

The most common treatment-related adverse reaction occurring in clinical trials was application site pain, such as burning or stinging.

Please see Full Prescribing Information and Patient Information

Indication EUCRISA is indicated for topical treatment of mild-to-moderate atopic dermatitis in adult and pediatric patients 3 months of age and older.Important Safety Information Contraindications

EUCRISA is contraindicated in patients with known hypersensitivity to crisaborole or any component of the formulation.

Warnings and Precautions

Hypersensitivity reactions, including contact urticaria, have occurred in patients treated with EUCRISA and should be suspected in the event of severe pruritus, swelling, and erythema at the application site or at a distant site. Discontinue EUCRISA immediately and initiate appropriate therapy if signs and symptoms of hypersensitivity occur.

Adverse Reactions

The most common treatment-related adverse reaction occurring in clinical trials was application site pain, such as burning or stinging.

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